Menopause Linked to Faster Progression of Multiple Sclerosis in Women, Study Finds

What is multiple sclerosis?

Symptoms of MS

The connection between multiple sclerosis and menopause

Common symptoms of MS include:

  • Numbness or tingling.
  • Electric shock sensation during certain neck movements, especially bending the neck forward (Lhermitte’s sign).
  • Lack of coordination
  • Difficulty walking or inability to walk.
  • Weakness
  • Partial or complete loss of vision, usually in one eye, often with pain when moving the eye.
  • Double vision or blurred vision.
  • Dizziness or vertigo (false sensation of movement).
  • Problems with sexual function, bowel and bladder function.
  • Fatigue
  • Unintelligible speech
  • Challenges with memory, thinking and comprehension.
  • Mood swings.

What connects menopause to MS?

Menopause has a major negative impact on cognitive function, fine motor skills, and walking ability, while also accelerating the progression of multiple sclerosis (MS), according to a recent study by scientists at the University of California, San Francisco.

The researchers found that the blood biomarker neurofilament light chain (NfL) increased after menopause. This supports the MSFC findings and indicates increased nerve cell destruction, a hallmark of progressive MS.

How was the study conducted?

The connection between multiple sclerosis and menopause

Using data from two UCSF studies investigating the etiology and course of MS, EPIC and ORIGINS, the study followed 184 pre- and postmenopausal women. The researchers used the MS Functional Composite (MSFC) to measure walking speed and other tasks during annual assessments of participants, which lasted an average of 13 years.

The study used the MS Functional Composite (MSFC), which measures walking speed among other tasks. After controlling for age, weight, and tobacco use, they found that after menopause, participants took longer to walk 25 feet. Other small declines in cognition and skills were also found.

Related: How Multiple Sclerosis Is Different in Men and Women

Does MS affect more women than men?

MS primarily affects women, and there is evidence that the course of the disease may be influenced by changes in sex hormones, such as estrogen. Because estrogen levels decrease during menopause, there is reason to believe that menopause may have an impact on the course of MS.

Menopause can worsen MS symptoms in some people. For some people, menopausal hot flashes can worsen or temporarily worsen problems with heat sensitivity, which can make symptoms worse. Mood, sleep, fatigue, cognition, or bladder function problems can all be more difficult during menopause.

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